Years of Research.
And Science.
Upon interacting with antigen-presenting cells (APCs), resting T cells transform into powerful activated T cells, ready to target and eliminate pathogens. VisAcT (18F-AraG) preferentially accumulates in activated T cells, enabling their tracking throughout the body.
Activated T cells can recognize and attack abnormal cells and viruses, but in autoimmune disorders, they may also target normal tissues. VisAcT (18F-AraG) is a valuable tool for assessing T cell function across various diseases.
Immunoncology Applications
A baseline PET scan with VisAcT® can help determine if a patient is immune-ready for immunotherapy or if immune priming is needed before starting treatment.
VisAcT® PET scans performed early in the treatment may help assess whether a patient’s immune system is responding effectively to immunotherapy.
An on-treatment VisAcT® scan may reveal cytotoxic T cell accumulation in off-target tissues, allowing timely interventions and prevention of severe adverse events.
Other Applications
Neuroinflammation contributes to the progression and severity of neurodegenerative conditions such as multiple sclerosis, Alzheimer’s and Parkinson’s diseases. Imaging neuroinflammation is crucial for understanding neurological disorders, developing targeted treatments and improving patient outcomes.
VisAcT® can assess mitochondrial function in cardiomyocytes enabling early detection of cardiotoxicity and assessment of myocardial viability.